| Label | Markers |
|---|
| aDC1 | LAMP3, RASSF4, FSCN1, MARCKS, TNFAIP2, TYROBP, CSF2RA, GSN, TMEM176B, IDO1 |
| aDC2 | S100B, LAMP3, CCL22, SHTN1, S100A2, SDC4, PRDM16, GJA1, FLT3, AC090559.1 |
| aDC3 | FSCN1, LGALS2, IDO1, RASSF4, CST3, CCL19, TYROBP, LAMP3, TMEM176A, TMEM176B |
| Basal cells | S100A8, KRT5, SFN, S100A2, KRT14, SPINK5, S100A14, KRT6A, S100A16, KRT13 |
| C1Q Slan-like | LYZ, CST3, C1QA, C1QC, C1QB, TYROBP, AIF1, FCER1G, MMP9, TMEM176B |
| CD14+CD55+ FDC | VCAM1, IGFBP7, RARRES2, SERPINE2, CXCL13, ANKRD29, CXCL14, NOVA1, TNFAIP2, CALD1 |
| CD16-CD56+ NK | GNLY, KLRD1, NKG7, TYROBP, CTSW, TRDC, FCER1G, ID2, XCL2, PRF1 |
| CD16-CD56dim NK | KLRD1, TYROBP, NKG7, GNLY, TRDC, CTSW, FCER1G, KLRK1, IL2RB, KLRB1 |
| CD16+CD56- NK | NKG7, KLRD1, GNLY, GZMA, PRF1, CST7, GZMB, CTSW, CCL4, GZMH |
| CD8 Tf | GZMK, CST7, CCL5, NKG7, GZMA, IL32, CCL4, EOMES, SH2D1A, CD8A |
| CM CD8 T | IL7R, CCL5, IL32, ANXA1, GIMAP7, CD3D, GIMAP4, CD3E, CD3G, CD2 |
| CM Pre-non-Tfh | IL7R, GIMAP7, CD3D, IL32, CD3G, GIMAP4, CD3E, FYB1, CD2, ANXA1 |
| CM PreTfh | IL7R, FYB1, GIMAP7, CD3D, CD3G, BCL11B, CD3E, IL6ST, IL32, GIMAP4 |
| COL27A1+ FDC | TNFAIP2, CLU, MAP1LC3A, ANKRD29, NFIA, FDCSP, DST, NOVA1, TPM1, EPHX2 |
| Crypt | CSTA, KRT19, CCL20, IDO1, MT3, IFI27, FXYD3, SPINK5, S100P, HPGD |
| csMBC | BANK1, TNFRSF13B, ADAM28, LINC01781, AIM2, MARCH1, SCIMP, BHLHE41, ARHGAP24, SMIM14 |
| csMBC FCRL4/5+ | FCRL4, TNFRSF13B, BHLHE41, FCRL5, ENTPD1, CCR6, CCDC50, PTPN1, ZEB2, CAPG |
| Cycling | LYZ, CST3, LGALS2, MS4A6A, TYROBP, S100B, FCER1G, C1QA, C1QC, IGSF6 |
| cycling FDC | CLU, FDCSP, PTGDS, CSTA, IGFBP7, RARRES2, CXCL13, SERPINE2, G0S2, MAP1LC3A |
| cycling T | CD3D, CD3E, CD3G, CD2, FYB1, IL32, STMN1, LAT, BCL11B, TRAC |
| DC recruiters CD8 T | NKG7, CCL5, GZMK, CST7, GZMA, KLRK1, CCL4, IL32, KLRG1, KLRD1 |
| DC1 mature | CPVL, FGL2, DNASE1L3, LGALS2, CST3, SHTN1, LYZ, IDO1, C1orf54, ID2 |
| DC1 precursor | LGALS2, CST3, LYZ, DNASE1L3, CPVL, IDO1, S100B, RAB32, RGCC, C1orf54 |
| DC2 | TYROBP, LGALS2, CST3, LYZ, FGL2, FCER1G, IGSF6, CPVL, JAML, MNDA |
| DC3 | FCER1G, CPVL, CFP, TYROBP, IGSF6, FCN1, LGALS2, AC020656.1, VCAN, IL1B |
| DC4 | TYROBP, FGL2, LYZ, SERPINA1, LGALS2, CST3, IGSF6, FCER1G, CPVL, KCTD12 |
| DC5 | LST1, JAML, LYZ, CST3, TYROBP, GSN, HCK, PAK1, CLEC4A, FGL2 |
| DN | GZMK, NUCB2, MT2A, CD3G, LYST, GIMAP5, SH2D1A, GIMAP4, CD3D, GIMAP7 |
| DZ cell cycle exit | STMN1, PTTG1, HMGB2, H2AFV, RGS13, SEC14L1, CENPF, BIRC5, AICDA, MEF2B |
| DZ early G2Mphase | TOP2A, UBE2C, TPX2, MKI67, CDK1, NUSAP1, ASPM, HIST1H1B, CENPF, GTSE1 |
| DZ early Sphase | MCM4, PCLAF, GINS2, STMN1, HELLS, MCM7, SLBP, CDCA7, CLSPN, MCM3 |
| DZ late G2Mphase | CDC20, CCNB2, CCNB1, HMMR, TPX2, CENPF, CDKN3, TOP2A, ASPM, BIRC5 |
| DZ late Sphase | RRM2, HIST1H1B, MKI67, PCLAF, TYMS, NUSAP1, TK1, CLSPN, MCM7, CENPM |
| DZ migratory PC precursor | EPDR1, IGHVIII-38-1, AC246787.2, LINC02362, DERL3, FKBP11, SLAMF7, IGLV1-50, FNDC3B, IGHGP |
| DZ non proliferative | SUGCT, MEF2B, NEIL1, SEC14L1, AICDA, BCL7A, MME, BACH2, TCL1A, CD38 |
| DZ_LZ transition | MEF2B, RGS13, SERPINA9, LMO2, HMCES, KLHL6, LRMP, FGD6, MARCKSL1, NEIL1 |
| Early GC-commited NBC | EGR3, CD83, PHACTR1, CD69, IGHD, FCER2, CD72, NFKBID, BANK1, DUSP2 |
| Early MBC | HTR3A, NEIL1, BANK1, IGHD, HRK, ACP5, SMIM14, CR2, LTB, MIR3681HG |
| Early PC precursor | RASSF6, NKX6-3, FMNL2, FRZB, SPARCL1, TMEM52B, PPP1R17, LINC01484, ETV7, PRDM1 |
| Eff-Tregs | MAF, CD2, IL32, CD3D, CD3E, CYTOR, TNFRSF1B, CD3G, FYB1, PBXIP1 |
| Eff-Tregs-IL32 | IL32, CD3D, S100A4, RTKN2, CD3E, CD2, PRDM1, CD3G, TIGIT, FYB1 |
| EM CD8 T | NKG7, CCL5, GZMA, CST7, GZMH, CTSW, CCL4, GNLY, PRF1, KLRD1 |
| FDC | CLU, FDCSP, CSTA, PTGDS, CXCL13, IGFBP7, RARRES2, SERPINE2, MARCKS, G0S2 |
| FDCSP epithelium | S100A8, KRT6A, S100A14, SFN, SPINK5, S100A16, PERP, SPRR1B, SPRR2A, RHCG |
| FRC | C5AR2, SPINK5, PBX1, LTF, NFASC, FRK, MIR205HG, ST5, ACOT11, ARHGAP29 |
| GC DZ Noproli | IGHV1-45, AL157373.2, AC125437.3, MEX3A, RFX3-AS1, TCL6, AP000424.1, C1orf61, DCAF12, NEIL1 |
| GC-commited NBC | CD83, FCER2, NME1, PHACTR1, SYNGR2, CCND2, DDX21, CD72, PARP14, MIR155HG |
| GC-Tfh-OX40 | CD3D, CD2, GBP2, TIGIT, ITM2A, MAF, CD200, SRGN, CD3E, TBC1D4 |
| GC-Tfh-SAP | TOX2, CD3D, CD2, TIGIT, PDCD1, ITM2A, MAF, CD3E, LAT, CD3G |
| IFN+ CD8 T | IFIT1, CCL5, GZMK, IFI6, IFI44L, NKG7, RSAD2, IFI44, CST7, GZMA |
| IFN1+ PDC | GZMB, LILRA4, TYROBP, DNASE1L3, FCER1G, CST3, SERPINF1, SMPD3, IL3RA, LILRB4 |
| IgD PC precursor | DERL3, FKBP11, SDF2L1, MANF, DNAJB9, PRDX4, TXNDC5, CRELD2, AC012236.1, SLAMF7 |
| IgG+ PC precursor | DERL3, FKBP11, XBP1, TXNDC5, MZB1, PDIA4, AC012236.1, JCHAIN, SELENOS, RRBP1 |
| IgM+ early PC precursor | VPREB1, ALDOB, C4BPB, LINC01551, RASSF6, NKX6-3, GIPC2, LINC02362, ABCA12, SPARCL1 |
| IgM+ PC precursor | RASSF6, LINC02362, CKAP4, VDR, CCR10, LINC01484, ADM, RHBDL1, CTHRC1, AP000542.2 |
| IL7R DC | TYROBP, CST3, C15orf48, LYZ, LGALS2, CSF2RA, FCER1G, CPVL, FPR1, IL4I1 |
| ILC1 | KLRB1, FCER1G, TYROBP, CTSW, TRDC, ID2, TNFRSF18, GNLY, XCL2, FXYD7 |
| ITGAX Slan-like | RASSF4, DST, IL18, ITGAX, TFEC, DMXL2, TLR4, LINC00996, NR1H3, NAIP |
| LZ | RGS13, LMO2, MEF2B, SERPINA9, GMDS, FGD6, KLHL6, BCL2A1, LRMP, RFTN1 |
| LZ proliferative | NME1, FABP5, STMN1, HNRNPAB, MCM7, PAICS, HELLS, RANBP1, MKI67, MCM3 |
| LZ_DZ reentry commitment | LMO2, BCL2A1, RGS13, NME1, GMDS, MEF2B, DUSP2, CD83, OTULIN, FABP5 |
| LZ_DZ transition | PCLAF, NME1, FABP5, PCNA, MCM7, MCM4, TYMS, PAICS, STMN1, GMNN |
| M1 Macrophages | TYROBP, FCER1G, SERPINA1, LYZ, S100A9, TIMP1, C15orf48, S100A8, IER3, LGALS3 |
| MAIT/CD161+TRDV2+ gd T-cells | CCL5, NKG7, GZMK, GZMA, KLRB1, IL7R, IL32, S100A4, CST7, ANXA1 |
| Mast | CPA3, TPSB2, TPSAB1, MS4A2, FCER1G, CLU, VWA5A, LTC4S, TYROBP, HPGD |
| Mature IgA+ PC | DERL3, FKBP11, MZB1, XBP1, JCHAIN, PRDX4, TXNDC5, SEC11C, IGHA1, MANF |
| Mature IgG+ PC | FKBP11, PRDX4, DERL3, XBP1, MZB1, IGHG4, IGHG3, ITM2C, SEC11C, IGHG1 |
| Mature IgM+ PC | DERL3, FKBP11, LINC02362, AC147651.1, AC074212.1, TXNDC5, XBP1, PRDX4, SLAMF7, DNAJB9 |
| MBC derived early PC precursor | DERL3, MZB1, FKBP11, XBP1, PRDX4, IGHG3, SSR4, IGHGP, IGHG1, IGHG4 |
| MBC derived IgA+ PC | DERL3, TXNDC5, FKBP11, XBP1, MZB1, SELENOS, PRDM1, JCHAIN, PDIA4, PRDX4 |
| MBC derived IgG+ PC | FKBP11, DERL3, XBP1, PRDX4, MZB1, TENT5C, ITM2C, TXNDC5, SELENOS, SEC11C |
| MBC derived PC precursor | DERL3, FKBP11, TXNDC5, LINC02362, SLAMF7, FNDC3B, SDC1, XBP1, TENT5C, MZB1 |
| MBC FCRL5+ | FCRL5, SCIMP, HOPX, CPNE5, IFI30, BANK1, BHLHE41, CTSH, TNFRSF13B, HLA-DQB1 |
| MMP Slan-like | TMEM176B, C1QA, LYZ, TYROBP, CST3, C1QB, FCER1G, CD68, C1QC, MMP9 |
| Monocytes | TYROBP, LYZ, FCER1G, S100A9, CST3, FGL2, FCN1, MNDA, S100A8, AIF1 |
| MRC | CALD1, DST, IGFBP7, COL1A2, COL6A3, DCN, ROBO1, RARRES2, ABI3BP, AEBP1 |
| Naive | GIMAP7, CD3D, CD3E, CD3G, FYB1, IL7R, GIMAP4, TCF7, BCL11B, CD7 |
| Naive CD8 T | CD8B, CD3D, CD3E, GIMAP7, CD3G, CD8A, IL7R, CD7, LINC02446, KLRK1 |
| NBC | IGHD, IGHM, TCL1A, BANK1, FCER2, HLA-DQB1, LINC02397, CD72, HLA-DQA1, HVCN1 |
| NBC CD229+ | LINC01857, PARP15, OAS1, FCRL5, FCMR, LILRA4, ACP5, FCRL2, PHACTR1, TCF4 |
| NBC early activation | IGHD, IGHM, ADAM28, BANK1, TCL1A, FCER2, LINC00926, HVCN1, LINC02397, MARCH1 |
| NBC IFN-activated | IFIT3, IFI44L, IFIT1, ISG15, XAF1, MX1, SAMD9L, EPSTI1, STAT1, MX2 |
| ncsMBC | TNFRSF13B, ARHGAP24, BANK1, CD24, TCF4, FCRL2, CD1C, IGHM, RALGPS2, CCDC50 |
| ncsMBC FCRL4/5+ | TNFRSF13B, FCRL4, ACP5, CCR6, CCDC50, BHLHE41, PTPN1, BANK1, IFI30, FCRL5 |
| Neutrophils | SOD2, NAMPT, CXCL8, S100A9, G0S2, S100A8, TYROBP, FCER1G, MXD1, GLUL |
| NKp44- ILC3 | AC244502.1, LINC00299, IGFBP7, KIT, IL23R, DPPA4, RORC, HOXA9, AC004540.2, MRC2 |
| NKp44+ ILC3 | TYROBP, KLRB1, CTSW, IL7R, ID2, TNFRSF18, FCER1G, LINC00299, PCDH9, JAML |
| Outer surface | IL1RN, SPRR1B, SPRR3, SPRR2D, SPRR2E, SPRR2A, NCCRP1, LCE3D, LCN2, RHCG |
| PB | XBP1, MZB1, FKBP11, SDF2L1, DERL3, TXNDC5, SEC11C, JCHAIN, MANF, SSR3 |
| PB committed early PC precursor | VDR, CCR10, CFAP54, SPARCL1, KRT5, DENND6B, RASSF6, PRDM1, CKAP4, CD9 |
| PC committed Light Zone GCBC | RGS13, MEF2B, RASSF6, HMCES, CCDC88A, DHRS9, KLHL6, LRMP, AC023590.1, FAM3C |
| PDC | GZMB, LILRA4, IL3RA, TYROBP, CST3, FCER1G, SERPINF1, ITM2C, MPEG1, IRF7 |
| preB | IGLL1, ACSM3, VPREB1, ARPP21, AKAP12, BMP3, RAG1, DNTT, RIMS3, RARA-AS1 |
| Precursor MBCs | MEF2B, RGS13, BASP1, LRMP, TCL1A, MARCKSL1, SWAP70, CD22, TNFRSF13C, RFTN1 |
| preGC | PRDX1, YBX1, NME2, HSP90AB1, MIF, NPM1, EIF4A1, FABP5, LMO2, BASP1 |
| preMature IgG+ PC | DERL3, FKBP11, XBP1, MZB1, PRDX4, SEC11C, ITM2C, IGHG3, IGHG4, JCHAIN |
| preMature IgM+ PC | XBP1, LINC02362, FKBP11, DERL3, PRDM1, TXNDC5, CREB3L2, ELL2, SLAMF7, CKAP4 |
| preT | CD1E, ARPP21, RAG1, DNTT, LINC01226, AL138899.1, CD1B, CASC15, ELOVL4, PTCRA |
| Proliferative NBC | IGHD, BANK1, RALGPS2, FCER2, LINC02397, MEF2C, NCF1, PARP14, PLAC8, PHACTR1 |
| Reactivated proliferative MBCs | STMN1, PCLAF, MKI67, TYMS, HMGB2, SMC4, SMC2, NUSAP1, DUT, LMNB1 |
| RM CD8 activated T | GZMK, CCL5, NKG7, GZMA, CST7, CCL4, IL32, CD3D, CD2, GIMAP7 |
| RM CD8 T | GZMK, CCL5, NKG7, CST7, GZMA, CCL4, IL32, CD2, KLRG1, GIMAP7 |
| SCM CD8 T | IL7R, LINC00861, CCL5, GZMK, CD8A, CST7, CD8B, KLRK1, GZMA, NKG7 |
| SELENOP Slan-like | LYZ, AIF1, APOE, APOC1, CST3, IL18, TYROBP, ATOX1, PTGDS, LGALS1 |
| Short lived IgM+ PC | FKBP11, TXNDC5, DERL3, AC012236.1, CKAP4, LINC02362, CHPF, ELL2, LINC01484, B9D1 |
| Surface epithelium | IL1RN, S100A8, NDRG2, S100A9, SPRR3, TMPRSS11B, KRT13, DUSP5, LCN2, ECM1 |
| T-Eff-Mem | MAF, CD2, KLRB1, CD3D, GIMAP7, FYB1, GIMAP4, CD3E, CD3G, IL32 |
| T-helper | KLRB1, MAF, CD2, RORA, CD3D, SPOCK2, CD3G, CD3E, GIMAP7, IL32 |
| T-Trans-Mem | KLRB1, IL7R, CD2, GIMAP7, CD3D, RORA, IL32, S100A4, GIMAP4, CD3E |
| TCRVδ+ gd T | CCL5, KLRK1, IL32, GZMK, TRGC2, CD7, NKG7, KLRD1, TRG-AS1, GZMM |
| Tfh T:B border | FYB1, CD3D, IL6ST, IL7R, GIMAP7, CD2, IL32, MAF, SRGN, FYN |
| Tfh-LZ-GC | CD3D, FYB1, CD2, IL32, GIMAP7, MAF, CD3E, CD3G, GIMAP4, PASK |
| Tfh-Mem | MAF, CD2, IL32, CD3D, CD3E, KLRB1, CD3G, GIMAP7, TBC1D4, TRAC |
| Tfr | IL32, RTKN2, CD3D, CD3E, CD3G, TIGIT, IL7R, FYB1, S100A4, GIMAP7 |
| Transitional PB | KIAA0319, AL109761.1, C4BPB, NPIPB6, CKAP4, GGH, GMPPB, AC012447.1, TXNDC5, AP001160.3 |
| VEGFA+ | TNFAIP2, SPINK5, ITGB8, PDLIM3, RHCG, MIR205HG, DSC2, PTPRF, SFN, VEGFA |
| ZNF683+ CD8 T | NKG7, CCL5, KLRD1, CTSW, GNLY, CST7, KLRK1, ID2, LINC01871, CD8A |
